Design, synthesis and biological assessment of new 1-benzyl-4-((4-oxoquinazolin-3(4H)-yl)methyl) pyridin-1-ium derivatives (BOPs) as potential dual inhibitors of acetylcholinesterase and butyrylcholinesterase

Alzheimer's disease (AD), is among the most growing neurodegenerative diseases, which is mainly caused by the acetylcholine neurotransmitter loss in the hippocampus and cortex. Emerging of the dual Acetylcholinesterase (AChE)/Butyrylcholinesterase (BuChE) inhibitors has increased for treating A...

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Detalhes bibliográficos
Publicado no:Heliyon
Main Authors: Zarei, Samaneh, Shafiei, Mohammad, Firouzi, Maryam, Firoozpour, Loghman, Divsalar, Kouros, Asadipour, Ali, Akbarzadeh, Tahmineh, Foroumadi, Alireza
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8045006/
https://ncbi.nlm.nih.gov/pubmed/33869871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.heliyon.2021.e06683
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