Design, synthesis, and evaluation of novel cinnamic acid-tryptamine hybrid for inhibition of acetylcholinesterase and butyrylcholinesterase

BACKGROUND: Acetylcholine deficiencies in hippocampus and cortex, aggregation of β-amyloid, and β-secretase over activity have been introduced as main reasons in pathogenesis of Alzheimer’s disease. METHODS: Colorimetric Ellman’s method was used for determination of IC(50) value in AChE and BChE inh...

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Detalhes bibliográficos
Publicado no:Daru
Main Authors: Ghafary, Shahrzad, Ghobadian, Roshanak, Mahdavi, Mohammad, Nadri, Hamid, Moradi, Alireza, Akbarzadeh, Tahmineh, Najafi, Zahra, Sharifzadeh, Mohammad, Edraki, Najmeh, Moghadam, Farshad Homayouni, Amini, Mohsen
Formato: Artigo
Idioma:Inglês
Publicado em: Springer International Publishing 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7704987/
https://ncbi.nlm.nih.gov/pubmed/32372339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40199-020-00346-9
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