Mendelian Randomization With Refined Instrumental Variables From Genetic Score Improves Accuracy and Reduces Bias

Mendelian randomization (MR) can estimate the causal effect for a risk factor on a complex disease using genetic variants as instrument variables (IVs). A variety of generalized MR methods have been proposed to integrate results arising from multiple IVs in order to increase power. One of the method...

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Detalhes bibliográficos
Publicado no:Front Genet
Main Authors: Lin, Lijuan, Zhang, Ruyang, Huang, Hui, Zhu, Ying, Li, Yi, Dong, Xuesi, Shen, Sipeng, Wei, Liangmin, Chen, Xin, Christiani, David C., Wei, Yongyue, Chen, Feng
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Genetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8044958/
https://ncbi.nlm.nih.gov/pubmed/33868364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2021.618829
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