Sirt6 Regulates the Development of Medullary Thymic Epithelial Cells and Contributes to the Establishment of Central Immune Tolerance

Although some advances have been made in understanding the molecular regulation of mTEC development, the role of epigenetic regulators in the development and maturation of mTEC is poorly understood. Here, using the TEC-specific Sirt6 knockout mice, we found the deacetylase Sirtuin 6 (Sirt6) is essen...

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Bibliografiska uppgifter
I publikationen:Front Cell Dev Biol
Huvudupphovsmän: Zhang, Qian, Liang, Zhanfeng, Zhang, Jiayu, Lei, Tong, Dong, Xue, Su, Huiting, Chen, Yifang, Zhang, Zhaoqi, Tan, Liang, Zhao, Yong
Materialtyp: Artigo
Språk:Inglês
Publicerad: Frontiers Media S.A. 2021
Ämnen:
Cell and Developmental Biology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC8044826/
https://ncbi.nlm.nih.gov/pubmed/33869219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2021.655552
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