Sirt6 Regulates the Development of Medullary Thymic Epithelial Cells and Contributes to the Establishment of Central Immune Tolerance

Although some advances have been made in understanding the molecular regulation of mTEC development, the role of epigenetic regulators in the development and maturation of mTEC is poorly understood. Here, using the TEC-specific Sirt6 knockout mice, we found the deacetylase Sirtuin 6 (Sirt6) is essen...

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Bibliografiske detaljer
Udgivet i:Front Cell Dev Biol
Main Authors: Zhang, Qian, Liang, Zhanfeng, Zhang, Jiayu, Lei, Tong, Dong, Xue, Su, Huiting, Chen, Yifang, Zhang, Zhaoqi, Tan, Liang, Zhao, Yong
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2021
Fag:
Cell and Developmental Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8044826/
https://ncbi.nlm.nih.gov/pubmed/33869219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2021.655552
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