Systems Biology Guided Gene Enrichment Approaches Improve Prediction of Chronic Post-surgical Pain After Spine Fusion

OBJECTIVES: Incorporation of genetic factors in psychosocial/perioperative models for predicting chronic postsurgical pain (CPSP) is key for personalization of analgesia. However, single variant associations with CPSP have small effect sizes, making polygenic risk assessment important. Unfortunately...

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Detalhes bibliográficos
Publicado no:Front Genet
Main Authors: Chidambaran, Vidya, Pilipenko, Valentina, Jegga, Anil G., Geisler, Kristie, Martin, Lisa J.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Genetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8044807/
https://ncbi.nlm.nih.gov/pubmed/33868360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2021.594250
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