Computational Drug Repositioning and Experimental Validation of Ivermectin in Treatment of Gastric Cancer

Objective: The aim of the present study was repositioning of ivermectin in treatment of gastric cancer (GC) by computational prediction based on gene expression profiles of human and mouse model of GC and validations with in silico, in vitro and in vivo approaches. Methods: Computational drug reposi...

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Vydáno v:Front Pharmacol
Hlavní autoři: Rabben, Hanne-Line, Andersen, Gøran Troseth, Ianevski, Aleksandr, Olsen, Magnus Kringstad, Kainov, Denis, Grønbech, Jon Erik, Wang, Timothy Cragin, Chen, Duan, Zhao, Chun-Mei
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2021
Témata:
Pharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8044519/
https://ncbi.nlm.nih.gov/pubmed/33867984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2021.625991
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