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How do intrinsically disordered protein regions encode a driving force for liquid-liquid phase separation?

Liquid-liquid phase separation is the mechanism underlying the formation of biomolecular condensates. Disordered protein regions often drive phase separation, but molecular interactions of disordered protein regions are not well understood, sometimes leading to the conflation that all disordered pro...

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Bibliographic Details
Published in:Curr Opin Struct Biol
Main Authors: Borcherds, Wade, Bremer, Anne, Borgia, Madeleine B., Mittag, Tanja
Format: Artigo
Language:Inglês
Published: 2020
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8044266/
https://ncbi.nlm.nih.gov/pubmed/33069007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.sbi.2020.09.004
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