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How do intrinsically disordered protein regions encode a driving force for liquid-liquid phase separation?

Liquid-liquid phase separation is the mechanism underlying the formation of biomolecular condensates. Disordered protein regions often drive phase separation, but molecular interactions of disordered protein regions are not well understood, sometimes leading to the conflation that all disordered pro...

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Detalles Bibliográficos
Publicado en:Curr Opin Struct Biol
Autores principales: Borcherds, Wade, Bremer, Anne, Borgia, Madeleine B., Mittag, Tanja
Formato: Artigo
Lenguaje:Inglês
Publicado: 2020
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8044266/
https://ncbi.nlm.nih.gov/pubmed/33069007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.sbi.2020.09.004
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