Vitamin D and lumisterol derivatives can act on liver X receptors (LXRs)

The interactions of derivatives of lumisterol (L3) and vitamin D3 (D3) with liver X receptors (LXRs) were investigated. Molecular docking using crystal structures of the ligand binding domains (LBDs) of LXRα and β revealed high docking scores for L3 and D3 hydroxymetabolites, similar to those of the...

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Publicado no:Sci Rep
Main Authors: Slominski, Andrzej T., Kim, Tae-Kang, Qayyum, Shariq, Song, Yuwei, Janjetovic, Zorica, Oak, Allen S. W., Slominski, Radomir M., Raman, Chander, Stefan, Joanna, Mier-Aguilar, Carlos A., Atigadda, Venkatram, Crossman, David K., Golub, Andriy, Bilokin, Yaroslav, Tang, Edith K. Y., Chen, Jake Y., Tuckey, Robert C., Jetten, Anton M., Song, Yuhua
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8044163/
https://ncbi.nlm.nih.gov/pubmed/33850196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-87061-w
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