Inhibition of SARS-CoV-2 polymerase by nucleotide analogs: a single molecule perspective

The nucleotide analog Remdesivir (RDV) is the only FDA-approved antiviral therapy to treat infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The physical basis for efficient utilization of RDV by SARS-CoV-2 polymerase is unknown. Here, we characterize the impact of RDV and o...

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Vydáno v:bioRxiv
Hlavní autoři: Seifert, Mona, Bera, Subhas Chandra, van Nies, Pauline, Kirchdoerfer, Robert N., Shannon, Ashleigh, Le, Thi-Tuyet-Nhung, Meng, Xiangzhi, Xia, Hongjie, Wood, James M., Harris, Lawrence D., Papini, Flávia S., Arnold, Jamie J., Almo, Steven C., Grove, Tyler L., Shi, Pei-Yong, Xiang, Yan, Canard, Bruno, Depken, Martin, Cameron, Craig E., Dulin, David
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8043451/
https://ncbi.nlm.nih.gov/pubmed/33851161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.08.06.240325
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