Enhancing clinical and immunological effects of anti-PD-1 with belapectin, a galectin-3 inhibitor

BACKGROUND: PD-1/PD-L1 engagement and overexpression of galectin-3 (Gal-3) are critical mechanisms of tumor-induced immune suppression that contribute to immunotherapy resistance. We hypothesized that Gal-3 blockade with belapectin (GR-MD-02) plus anti-PD-1 (pembrolizumab) would enhance tumor respon...

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Detalhes bibliográficos
Publicado no:J Immunother Cancer
Main Authors: Curti, Brendan D, Koguchi, Yoshinobu, Leidner, Rom S, Rolig, Annah S, Sturgill, Elizabeth R, Sun, Zhaoyu, Wu, Yaping, Rajamanickam, Venkatesh, Bernard, Brady, Hilgart-Martiszus, Ian, Fountain, Christopher B, Morris, George, Iwamoto, Noriko, Shimada, Takashi, Chang, ShuChing, Traber, Peter G, Zomer, Eliezer, Horton, J Rex, Shlevin, Harold, Redmond, William L
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2021
Assuntos:
Clinical/Translational Cancer Immunotherapy
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8043038/
https://ncbi.nlm.nih.gov/pubmed/33837055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2021-002371
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