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Winding down: Selectively drugging a promiscuous pocket in cryptochrome lengthens circadian rhythms
Mammalian cryptochromes regulate sleep and metabolism as components of the circadian clock. In this issue of Cell Chemical Biology, Miller et al. (2020) use phenotypic chemical screens to identify selective modulators of two cryptochrome isoforms. Binding specificity depends on conformational patter...
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| Publicado no: | Cell Chem Biol |
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| Autor principal: | |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8042606/ https://ncbi.nlm.nih.gov/pubmed/32946755 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2020.08.002 |
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