Replication-stress-associated DSBs induced by ionizing radiation risk genomic destabilization and associated clonal evolution

Exposure to ionizing radiation is associated with cancer risk. Although multiple types of DNA damage are caused by radiation, it remains unknown how this damage is associated with cancer risk. Here, we show that after repair of double-strand breaks (DSBs) directly caused by radiation (dir-DSBs), irr...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:iScience
Prif Awduron: Matsuno, Yusuke, Hyodo, Mai, Suzuki, Mafuka, Tanaka, Yosuke, Horikoshi, Yasunori, Murakami, Yasufumi, Torigoe, Hidetaka, Mano, Hiroyuki, Tashiro, Satoshi, Yoshioka, Ken-ichi
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Elsevier 2021
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC8042347/
https://ncbi.nlm.nih.gov/pubmed/33870130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2021.102313
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