Replication stress triggers microsatellite destabilization and hypermutation leading to clonal expansion in vitro

Mismatch repair (MMR)-deficient cancers are characterized by microsatellite instability (MSI) and hypermutation. However, it remains unclear how MSI and hypermutation arise and contribute to cancer development. Here, we show that MSI and hypermutation are triggered by replication stress in an MMR-de...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Matsuno, Yusuke, Atsumi, Yuko, Shimizu, Atsuhiro, Katayama, Kotoe, Fujimori, Haruka, Hyodo, Mai, Minakawa, Yusuke, Nakatsu, Yoshimichi, Kaneko, Syuzo, Hamamoto, Ryuji, Shimamura, Teppei, Miyano, Satoru, Tsuzuki, Teruhisa, Hanaoka, Fumio, Yoshioka, Ken-ichi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6718401/
https://ncbi.nlm.nih.gov/pubmed/31477700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-11760-2
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