Replication stress triggers microsatellite destabilization and hypermutation leading to clonal expansion in vitro

Mismatch repair (MMR)-deficient cancers are characterized by microsatellite instability (MSI) and hypermutation. However, it remains unclear how MSI and hypermutation arise and contribute to cancer development. Here, we show that MSI and hypermutation are triggered by replication stress in an MMR-de...

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Udgivet i:Nat Commun
Main Authors: Matsuno, Yusuke, Atsumi, Yuko, Shimizu, Atsuhiro, Katayama, Kotoe, Fujimori, Haruka, Hyodo, Mai, Minakawa, Yusuke, Nakatsu, Yoshimichi, Kaneko, Syuzo, Hamamoto, Ryuji, Shimamura, Teppei, Miyano, Satoru, Tsuzuki, Teruhisa, Hanaoka, Fumio, Yoshioka, Ken-ichi
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6718401/
https://ncbi.nlm.nih.gov/pubmed/31477700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-11760-2
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