BCL11B is positioned upstream of PLZF and RORγt to control thymic development of mucosal-associated invariant T cells and MAIT17 program

Mucosal-associated invariant T (MAIT) cells recognize microbial riboflavin metabolites presented by MR1 and play role in immune responses to microbial infections and tumors. We report here that absence of the transcription factor (TF) Bcl11b in mice alters predominantly MAIT17 cells in the thymus an...

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Publicado en:iScience
Main Authors: Drashansky, Theodore T., Helm, Eric Y., Curkovic, Nina, Cooper, Jaimee, Cheng, Pingyan, Chen, Xianghong, Gautam, Namrata, Meng, Lingsong, Kwiatkowski, Alexander J., Collins, William O., Keselowsky, Benjamin G., Sant’Angelo, Derek, Huo, Zhiguang, Zhang, Weizhou, Zhou, Liang, Avram, Dorina
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2021
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8042176/
https://ncbi.nlm.nih.gov/pubmed/33870128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2021.102307
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