Structural plasticity of KIR2DL2 and KIR2DL3 enables altered docking geometries atop HLA-C

The closely related inhibitory killer-cell immunoglobulin-like receptors (KIR), KIR2DL2 and KIR2DL3, regulate the activation of natural killer cells (NK) by interacting with the human leukocyte antigen-C1 (HLA-C1) group of molecules. KIR2DL2, KIR2DL3 and HLA-C1 are highly polymorphic, with this vari...

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Udgivet i:Nat Commun
Main Authors: Moradi, Shoeib, Stankovic, Sanda, O’Connor, Geraldine M., Pymm, Phillip, MacLachlan, Bruce J., Faoro, Camilla, Retière, Christelle, Sullivan, Lucy C., Saunders, Philippa M., Widjaja, Jacqueline, Cox-Livingstone, Shea, Rossjohn, Jamie, Brooks, Andrew G., Vivian, Julian P.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8041999/
https://ncbi.nlm.nih.gov/pubmed/33846289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-22359-x
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