Metformin impairs cisplatin resistance effects in A549 lung cancer cells through mTOR signaling and other metabolic pathways

Lung cancer is the leading cause of cancer-associated death worldwide and exhibits intrinsic and acquired therapeutic resistance to cisplatin (CIS). The present study investigated the role of mTOR signaling and other signaling pathways after metformin (MET) treatment in control and cisplatin-resista...

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Pubblicato in:Int J Oncol
Autori principali: Morelli, Ana Paula, Tortelli, Tharcísio Citrângulo, Pavan, Isadora Carolina Betim, Silva, Fernando Riback, Granato, Daniela Campos, Peruca, Guilherme Francisco, Pauletti, Bianca Alves, Domingues, Romênia Ramos, Bezerra, Rosangela Maria Neves, De Moura, Leandro Pereira, Leme, Adriana Franco Paes, Chammas, Roger, Simabuco, Fernando Moreira
Natura: Artigo
Lingua:Inglês
Pubblicazione: D.A. Spandidos 2021
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8041480/
https://ncbi.nlm.nih.gov/pubmed/33846781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ijo.2021.5208
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