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Temporal, spatial, and genetic constraints contribute to the patterning and penetrance of murine neurofibromatosis-1 optic glioma

BACKGROUND: Brain tumors are the most common solid tumors of childhood, but little is understood about the factors that influence their development. Pediatric low-grade gliomas in particular display unique temporal and spatial localization associated with different genetic mutations (eg, BRAF genomi...

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Publicat a:Neuro Oncol
Autors principals: Brossier, Nicole M, Thondapu, Sharanya, Cobb, Olivia M, Dahiya, Sonika, Gutmann, David H
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2020
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8041339/
https://ncbi.nlm.nih.gov/pubmed/33080011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa237
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