TcpC inhibits toll-like receptor signaling pathway by serving as an E3 ubiquitin ligase that promotes degradation of myeloid differentiation factor 88

TcpC is a virulence factor of uropathogenic E. coli (UPEC). It was found that TIR domain of TcpC impedes TLR signaling by direct association with MyD88. It has been a long-standing question whether bacterial pathogens have evolved a mechanism to manipulate MyD88 degradation by ubiquitin-proteasome p...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Fang, Jia-qi, Ou, Qian, Pan, Jun, Fang, Jie, Zhang, Da-yong, Qiu, Miao-qi, Li, Yue-qi, Wang, Xiao-Hui, Yang, Xue-yu, Chi, Zhe, Gao, Wei, Guo, Jun-ping, Miethke, Thomas, Pan, Jian-ping
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8041205/
https://ncbi.nlm.nih.gov/pubmed/33788895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1009481
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