Substrate discrimination and quality control require each catalytic activity of TRAMP and the nuclear RNA exosome

Quality control requires discrimination between functional and aberrant species to selectively target aberrant substrates for destruction. Nuclear RNA quality control in Saccharomyces cerevisiae includes the TRAMP complex that marks RNA for decay via polyadenylation followed by helicase-dependent 3′...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Das, Mom, Zattas, Dimitrios, Zinder, John C., Wasmuth, Elizabeth V., Henri, Julien, Lima, Christopher D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2021
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8040639/
https://ncbi.nlm.nih.gov/pubmed/33782132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2024846118
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