Redefining the Histone Deacetylase Inhibitor Pharmacophore: High Potency with No Zinc Cofactor Interaction

[Image: see text] A novel series of histone deacetylase (HDAC) inhibitors lacking a zinc-binding moiety has been developed and described herein. HDAC isozyme profiling and kinetic studies indicate that these inhibitors display a selectivity preference for HDACs 1, 2, 3, 10, and 11 via a rapid equili...

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Argitaratua izan da:ACS Med Chem Lett
Egile Nagusiak: Beshore, Douglas C., Adam, Gregory C., Barnard, Richard J. O., Burlein, Christine, Gallicchio, Steven N., Holloway, M. Katharine, Krosky, Daniel, Lemaire, Wei, Myers, Robert W., Patel, Sangita, Plotkin, Michael A., Powell, David A., Rada, Vanessa, Cox, Christopher D., Coleman, Paul J., Klein, Daniel J., Wolkenberg, Scott E.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Chemical Society 2021
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC8040053/
https://ncbi.nlm.nih.gov/pubmed/33854701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.1c00074
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