Discovery of 2,4-1H-Imidazole Carboxamides as Potent and Selective TAK1 Inhibitors

[Image: see text] Herein we report the discovery of 2,4-1H-imidazole carboxamides as novel, biochemically potent, and kinome selective inhibitors of transforming growth factor β-activated kinase 1 (TAK1). The target was subjected to a DNA-encoded chemical library (DECL) screen. After hit analysis a...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Veerman, Johan J. N., Bruseker, Yorik B., Damen, Eddy, Heijne, Erik H., van Bruggen, Wendy, Hekking, Koen F. W., Winkel, Rob, Hupp, Christopher D., Keefe, Anthony D., Liu, Julie, Thomson, Heather A., Zhang, Ying, Cuozzo, John W., McRiner, Andrew J., Mulvihill, Mark J., van Rijnsbergen, Peter, Zech, Birgit, Renzetti, Louis M., Babiss, Lee, Müller, Gerhard
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2021
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8040042/
https://ncbi.nlm.nih.gov/pubmed/33859795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.0c00547
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados