Discovery of 2,4-1H-Imidazole Carboxamides as Potent and Selective TAK1 Inhibitors

[Image: see text] Herein we report the discovery of 2,4-1H-imidazole carboxamides as novel, biochemically potent, and kinome selective inhibitors of transforming growth factor β-activated kinase 1 (TAK1). The target was subjected to a DNA-encoded chemical library (DECL) screen. After hit analysis a...

Cijeli opis

Spremljeno u:
Bibliografski detalji
Izdano u:ACS Med Chem Lett
Glavni autori: Veerman, Johan J. N., Bruseker, Yorik B., Damen, Eddy, Heijne, Erik H., van Bruggen, Wendy, Hekking, Koen F. W., Winkel, Rob, Hupp, Christopher D., Keefe, Anthony D., Liu, Julie, Thomson, Heather A., Zhang, Ying, Cuozzo, John W., McRiner, Andrew J., Mulvihill, Mark J., van Rijnsbergen, Peter, Zech, Birgit, Renzetti, Louis M., Babiss, Lee, Müller, Gerhard
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2021
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8040042/
https://ncbi.nlm.nih.gov/pubmed/33859795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.0c00547
Oznake: Dodaj oznaku
Bez oznaka, Budi prvi tko označuje ovaj zapis!

Similar Items