Functionalized lipid nanoparticles for subcutaneous administration of mRNA to achieve systemic exposures of a therapeutic protein

Lipid nanoparticles (LNPs) are the most clinically advanced delivery system for RNA-based drugs but have predominantly been investigated for intravenous and intramuscular administration. Subcutaneous administration opens the possibility of patient self-administration and hence long-term chronic trea...

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Publicado no:Mol Ther Nucleic Acids
Main Authors: Davies, Nigel, Hovdal, Daniel, Edmunds, Nicholas, Nordberg, Peter, Dahlén, Anders, Dabkowska, Aleksandra, Arteta, Marianna Yanez, Radulescu, Aurel, Kjellman, Tomas, Höijer, Andreas, Seeliger, Frank, Holmedal, Elin, Andihn, Elisabeth, Bergenhem, Nils, Sandinge, Ann-Sofie, Johansson, Camilla, Hultin, Leif, Johansson, Marie, Lindqvist, Johnny, Björsson, Liselotte, Jing, Yujia, Bartesaghi, Stefano, Lindfors, Lennart, Andersson, Shalini
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2021
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8039535/
https://ncbi.nlm.nih.gov/pubmed/33868782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2021.03.008
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