Successful reprogramming of cellular protein production through mRNA delivered by functionalized lipid nanoparticles

The development of safe and efficacious gene vectors has limited greatly the potential for therapeutic treatments based on messenger RNA (mRNA). Lipid nanoparticles (LNPs) formed by an ionizable cationic lipid (here DLin-MC3-DMA), helper lipids (distearoylphosphatidylcholine, DSPC, and cholesterol),...

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Bibliografische gegevens
Gepubliceerd in:Proc Natl Acad Sci U S A
Hoofdauteurs: Yanez Arteta, Marianna, Kjellman, Tomas, Bartesaghi, Stefano, Wallin, Simonetta, Wu, Xiaoqiu, Kvist, Alexander J., Dabkowska, Aleksandra, Székely, Noémi, Radulescu, Aurel, Bergenholtz, Johan, Lindfors, Lennart
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2018
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PNAS Plus
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5899464/
https://ncbi.nlm.nih.gov/pubmed/29588418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1720542115
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