KRAS Mutational Regression Is Associated With Oligo-Metastatic Status and Good Prognosis in Metastatic Colorectal Cancer

BACKGROUND: We previously reported that loss of KRAS mutations (“regressive” mutational trajectories) from primary tumors to metastases associated with the oligo-metastatic status in colorectal cancer (CRC). The present study was undertaken in order to analyze the mutational trajectories of KRAS in...

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Bibliographic Details
Published in:Front Oncol
Main Authors: Ottaiano, Alessandro, Nasti, Guglielmo, Santorsola, Mariachiara, Altieri, Vincenzo, Di Fruscio, Giuseppina, Circelli, Luisa, Luce, Amalia, Cossu, Alessia Maria, Scognamiglio, Giosuè, Perri, Francesco, Correra, Marco, Belli, Andrea, Delrio, Paolo, Botti, Gerardo, Caraglia, Michele
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2021
Subjects:
Oncology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8039443/
https://ncbi.nlm.nih.gov/pubmed/33854968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2021.632962
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