Deletion of Alox15 improves kidney dysfunction and inhibits fibrosis by increased PGD(2) in the kidney

BACKGROUND: Lipid-metabolizing enzymes and their metabolites affect inflammation and fibrosis, but their roles in chronic kidney disease (CKD) have not been completely understood. METHODS: To clarify their role in CKD, we measured the mRNA levels of major lipid-metabolizing enzymes in 5/6 nephrectom...

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Vydáno v:Clin Exp Nephrol
Hlavní autoři: Takahashi, Naohiro, Kikuchi, Hiroaki, Usui, Ayaka, Furusho, Taisuke, Fujimaru, Takuya, Fujiki, Tamami, Yanagi, Tomoki, Matsuura, Yoshiaki, Asano, Kenichi, Yamamoto, Kouhei, Ando, Fumiaki, Susa, Koichiro, Mandai, Shintaro, Mori, Takayasu, Rai, Tatemitsu, Uchida, Shinichi, Arita, Makoto, Sohara, Eisei
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer Singapore 2021
Témata:
Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8038997/
https://ncbi.nlm.nih.gov/pubmed/33595729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10157-021-02021-y
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