Ultraconserved Enhancer Function Does Not Require Perfect Sequence Conservation

Ultraconserved enhancer sequences show perfect conservation between human and rodent genomes, suggesting that their functions are highly sensitive to mutation. However, current models of enhancer function do not sufficiently explain this extreme evolutionary constraint. We subjected 23 ultraconserve...

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Publicado no:Nat Genet
Main Authors: Snetkova, Valentina, Ypsilanti, Athena R., Akiyama, Jennifer A., Mannion, Brandon J., Plajzer-Frick, Ingrid, Novak, Catherine S., Harrington, Anne N., Pham, Quan T., Kato, Momoe, Zhu, Yiwen, Godoy, Janeth, Meky, Eman, Hunter, Riana D., Shi, Marie, Kvon, Evgeny Z., Afzal, Veena, Tran, Stella, Rubenstein, John L.R., Visel, Axel, Pennacchio, Len A., Dickel, Diane E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8038972/
https://ncbi.nlm.nih.gov/pubmed/33782603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-021-00812-3
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