Human-chimpanzee fused cells reveal cis-regulatory divergence underlying skeletal evolution

Gene regulatory divergence is thought to play a central role in determining human-specific traits. However, our ability to link divergent regulation to divergent phenotypes is limited. Here, we utilized human-chimpanzee hybrid induced pluripotent stem cells to study gene expression separating these...

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Publicado no:Nat Genet
Main Authors: Gokhman, David, Agoglia, Rachel M., Kinnebrew, Maia, Gordon, Wei, Sun, Danqiong, Bajpai, Vivek K., Naqvi, Sahin, Chen, Coral, Chan, Anthony, Chen, Chider, Petrov, Dmitri A., Ahituv, Nadav, Zhang, Honghao, Mishina, Yuji, Wysocka, Joanna, Rohatgi, Rajat, Fraser, Hunter B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8038968/
https://ncbi.nlm.nih.gov/pubmed/33731941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-021-00804-3
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