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Development of a Multimatrix UHPLC-MS/MS Method for the Determination of Paracetamol and Its Metabolites in Animal Tissues

Paracetamol/acetaminophen (APAP) is one of the most popular pharmacologically active substances used as an analgesic and antipyretic agent. The metabolism of this drug occurs in the liver and leads to the formation of two main metabolites—glucuronic acid and sulfate derivate. Despite the wide use of...

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Detalhes bibliográficos
Publicado no:Molecules
Main Authors: Pietruk, Konrad, Gbylik-Sikorska, Małgorzata, Łebkowska-Wieruszewska, Beata, Gajda, Anna, Giorgi, Mario, Sartini, Irene, Jedziniak, Piotr
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8038326/
https://ncbi.nlm.nih.gov/pubmed/33918518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules26072046
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