A Novel LRRK2 Variant p.G2294R in the WD40 Domain Identified in Familial Parkinson’s Disease Affects LRRK2 Protein Levels

Leucine-rich repeat kinase 2 (LRRK2) is a major causative gene of late-onset familial Parkinson’s disease (PD). The suppression of kinase activity is believed to confer neuroprotection, as most pathogenic variants of LRRK2 associated with PD exhibit increased kinase activity. We herein report a nove...

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發表在:Int J Mol Sci
Main Authors: Ogata, Jun, Hirao, Kentaro, Nishioka, Kenya, Hayashida, Arisa, Li, Yuanzhe, Yoshino, Hiroyo, Shimizu, Soichiro, Hattori, Nobutaka, Imai, Yuzuru
格式: Artigo
語言:Inglês
出版: MDPI 2021
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC8038167/
https://ncbi.nlm.nih.gov/pubmed/33918221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22073708
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