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An Evaluation of the Diagnostic Accuracy of a Panel of Variants in DPYD and a Single Variant in ENOSF1 for Predicting Common Capecitabine Related Toxicities

SIMPLE SUMMARY: 5-Fluorouracil (5-FU) is a chemotherapy drug that can cause severe toxicity in some patients. A protein, an action molecule in our cells, called dihydropyrimidine dehydrogenase, or DPD for short, is important in clearing 5-FU from the body. Some people have versions of DPD that do no...

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Dettagli Bibliografici
Pubblicato in:Cancers (Basel)
Autori principali: Palles, Claire, Fotheringham, Susan, Chegwidden, Laura, Lucas, Marie, Kerr, Rachel, Mozolowski, Guy, Rosmarin, Dan, Taylor, Jenny C., Tomlinson, Ian, Kerr, David
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2021
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8037940/
https://ncbi.nlm.nih.gov/pubmed/33805100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers13071497
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