New advances in DPYD genotype and risk of severe toxicity under capecitabine

BACKGROUND: Deficiency in dihydropyrimidine dehydrogenase (DPD) enzyme is the main cause of severe and lethal fluoropyrimidine-related toxicity. Various approaches have been developed for DPD-deficiency screening, including DPYD genotyping and phenotyping. The goal of this prospective observational...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Etienne-Grimaldi, Marie-Christine, Boyer, Jean-Christophe, Beroud, Christophe, Mbatchi, Litaty, van Kuilenburg, André, Bobin-Dubigeon, Christine, Thomas, Fabienne, Chatelut, Etienne, Merlin, Jean-Louis, Pinguet, Frédéric, Ferrand, Christophe, Meijer, Judith, Evrard, Alexandre, Llorca, Laurence, Romieu, Gilles, Follana, Philippe, Bachelot, Thomas, Chaigneau, Loic, Pivot, Xavier, Dieras, Véronique, Largillier, Rémy, Mousseau, Mireille, Goncalves, Anthony, Roché, Henri, Bonneterre, Jacques, Servent, Véronique, Dohollou, Nadine, Château, Yann, Chamorey, Emmanuel, Desvignes, Jean-Pierre, Salgado, David, Ferrero, Jean-Marc, Milano, Gérard
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5421769/
https://ncbi.nlm.nih.gov/pubmed/28481884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0175998
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