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Osmolality Effects on CHO Cell Growth, Cell Volume, Antibody Productivity and Glycosylation

The addition of nutrients and accumulation of metabolites in a fed-batch culture of Chinese hamster ovary (CHO) cells leads to an increase in extracellular osmolality in late stage culture. Herein, we explore the effect of osmolality on CHO cell growth, specific monoclonal antibody (mAb) productivit...

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Dades bibliogràfiques
Publicat a:Int J Mol Sci
Autors principals: Alhuthali, Sakhr, Kotidis, Pavlos, Kontoravdi, Cleo
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2021
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8037477/
https://ncbi.nlm.nih.gov/pubmed/33804825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22073290
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