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Effect of MgCl(2) and GdCl(3) on ORAI1 Expression and Store-Operated Ca(2+) Entry in Megakaryocytes
In chronic kidney disease, hyperphosphatemia upregulates the Ca(2+) channel ORAI and its activating Ca(2+) sensor STIM in megakaryocytes and platelets. ORAI1 and STIM1 accomplish store-operated Ca(2+) entry (SOCE) and play a key role in platelet activation. Signaling linking phosphate to upregulatio...
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| Udgivet i: | Int J Mol Sci |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
MDPI
2021
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8036595/ https://ncbi.nlm.nih.gov/pubmed/33804889 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22073292 |
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