Effect of MgCl(2) and GdCl(3) on ORAI1 Expression and Store-Operated Ca(2+) Entry in Megakaryocytes

In chronic kidney disease, hyperphosphatemia upregulates the Ca(2+) channel ORAI and its activating Ca(2+) sensor STIM in megakaryocytes and platelets. ORAI1 and STIM1 accomplish store-operated Ca(2+) entry (SOCE) and play a key role in platelet activation. Signaling linking phosphate to upregulatio...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Zhou, Kuo, Zhu, Xuexue, Ma, Ke, Liu, Jibin, Nürnberg, Bernd, Gawaz, Meinrad, Lang, Florian
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8036595/
https://ncbi.nlm.nih.gov/pubmed/33804889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22073292
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