Selective Activation of CNS and Reference PPARGC1A Promoters Is Associated with Distinct Gene Programs Relevant for Neurodegenerative Diseases

The transcriptional regulator peroxisome proliferator activated receptor gamma coactivator 1A (PGC-1α), encoded by PPARGC1A, has been linked to neurodegenerative diseases. Recently discovered CNS-specific PPARGC1A transcripts are initiated far upstream of the reference promoter, spliced to exon 2 of...

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Publicat a:Int J Mol Sci
Autors principals: Kwik, Markus, Hainzl, Stefan, Oppelt, Jan, Tichy, Boris, Koller, Ulrich, Bernardinelli, Emanuele, Steiner, Markus, Zara, Greta, Nofziger, Charity, Weis, Serge, Paulmichl, Markus, Dossena, Silvia, Patsch, Wolfgang, Soyal, Selma M.
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8036390/
https://ncbi.nlm.nih.gov/pubmed/33804860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22073296
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