Targeting Replicative Stress and DNA Repair by Combining PARP and Wee1 Kinase Inhibitors Is Synergistic in Triple Negative Breast Cancers with Cyclin E or BRCA1 Alteration

SIMPLE SUMMARY: Triple-negative breast cancer (TNBC) is a subtype of invasive breast cancer with an aggressive phenotype that has decreased survival compared with other types of breast cancers, due in part to the lack of biomarker driven targeted therapies. Here, we show that breast cancer patients...

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Detalhes bibliográficos
Publicado no:Cancers (Basel)
Main Authors: Chen, Xian, Yang, Dong, Carey, Jason P. W., Karakas, Cansu, Albarracin, Constance, Sahin, Aysegul A., Arun, Banu K., Guray Durak, Merih, Li, Mi, Kohansal, Mehrnoosh, Bui, Tuyen N., Ha, Min-Jin, Hunt, Kelly K., Keyomarsi, Khandan
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8036262/
https://ncbi.nlm.nih.gov/pubmed/33916118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers13071656
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