Targeting Replicative Stress and DNA Repair by Combining PARP and Wee1 Kinase Inhibitors Is Synergistic in Triple Negative Breast Cancers with Cyclin E or BRCA1 Alteration

SIMPLE SUMMARY: Triple-negative breast cancer (TNBC) is a subtype of invasive breast cancer with an aggressive phenotype that has decreased survival compared with other types of breast cancers, due in part to the lack of biomarker driven targeted therapies. Here, we show that breast cancer patients...

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Bibliographic Details
Published in:Cancers (Basel)
Main Authors: Chen, Xian, Yang, Dong, Carey, Jason P. W., Karakas, Cansu, Albarracin, Constance, Sahin, Aysegul A., Arun, Banu K., Guray Durak, Merih, Li, Mi, Kohansal, Mehrnoosh, Bui, Tuyen N., Ha, Min-Jin, Hunt, Kelly K., Keyomarsi, Khandan
Format: Artigo
Language:Inglês
Published: MDPI 2021
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8036262/
https://ncbi.nlm.nih.gov/pubmed/33916118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers13071656
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