Induction of Wnt signaling antagonists and p21-activated kinase enhances cardiomyocyte proliferation during zebrafish heart regeneration

Heart regeneration occurs by dedifferentiation and proliferation of pre-existing cardiomyocytes (CMs). However, the signaling mechanisms by which injury induces CM renewal remain incompletely understood. Here, we find that cardiac injury in zebrafish induces expression of the secreted Wnt inhibitors...

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Publicat a:J Mol Cell Biol
Autors principals: Peng, Xiangwen, Lai, Kaa Seng, She, Peilu, Kang, Junsu, Wang, Tingting, Li, Guobao, Zhou, Yating, Sun, Jianjian, Jin, Daqing, Xu, Xiaolei, Liao, Lujian, Liu, Jiandong, Lee, Ethan, Poss, Kenneth D, Zhong, Tao P
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2020
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8035995/
https://ncbi.nlm.nih.gov/pubmed/33582796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jmcb/mjaa046
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