Poly(ethylene glycol)-poly(beta-amino ester)-based nanoparticles for suicide gene therapy enhance brain penetration and extend survival in a preclinical human glioblastoma orthotopic xenograft model

Glioblastoma (GBM) is the most devastating brain cancer, and cures remain elusive with currently available neurosurgical, pharmacological and radiation approaches. While retrovirus- and adenovirus-mediated suicide gene therapy using DNA encoding herpes simplex virus-thymidine kinase (HSV-tk) and pro...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:ACS Biomater Sci Eng
Auteurs principaux: Kim, Jayoung, Mondal, Sujan K., Tzeng, Stephany Y., Rui, Yuan, Al-kharboosh, Rawan, Kozielski, Kristen K., Bhargav, Adip G., Garcia, Cesar A., Quiñones-Hinojosa, Alfredo, Green, Jordan J.
Format: Artigo
Langue:Inglês
Publié: 2020
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8035708/
https://ncbi.nlm.nih.gov/pubmed/33463272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsbiomaterials.0c00116
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires