Poly(ethylene glycol)-poly(beta-amino ester)-based nanoparticles for suicide gene therapy enhance brain penetration and extend survival in a preclinical human glioblastoma orthotopic xenograft model

Glioblastoma (GBM) is the most devastating brain cancer, and cures remain elusive with currently available neurosurgical, pharmacological and radiation approaches. While retrovirus- and adenovirus-mediated suicide gene therapy using DNA encoding herpes simplex virus-thymidine kinase (HSV-tk) and pro...

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Veröffentlicht in:ACS Biomater Sci Eng
Hauptverfasser: Kim, Jayoung, Mondal, Sujan K., Tzeng, Stephany Y., Rui, Yuan, Al-kharboosh, Rawan, Kozielski, Kristen K., Bhargav, Adip G., Garcia, Cesar A., Quiñones-Hinojosa, Alfredo, Green, Jordan J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8035708/
https://ncbi.nlm.nih.gov/pubmed/33463272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsbiomaterials.0c00116
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