Association of genetic variation with cirrhosis: a multi-trait genome-wide association and gene-environment interaction study

BACKGROUND: In contrast to most other common diseases, few genetic variants have been identified that impact risk of cirrhosis. We aimed to identify new genetic variants that predispose to cirrhosis, to test whether such variants, aggregated into a polygenic score, enable genomic risk stratification...

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Veröffentlicht in:Gastroenterology
Hauptverfasser: Emdin, Connor A, Haas, Mary, Ajmera, Veeral, Simon, Tracey G, Homburger, Julian, Neben, Cynthia, Jiang, Lan, Wei, Wei-Qi, Feng, Qiping, Zhou, Alicia, Denny, Joshua, Corey, Kathleen, Loomba, Rohit, Kathiresan, Sekar, Khera, Amit V
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8035329/
https://ncbi.nlm.nih.gov/pubmed/33310085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2020.12.011
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