Dynamic extrinsic pacing of the HOX clock in human axial progenitors controls motor neuron subtype specification

Rostro-caudal patterning of vertebrates depends on the temporally progressive activation of HOX genes within axial stem cells that fuel axial embryo elongation. Whether the pace of sequential activation of HOX genes, the 'HOX clock', is controlled by intrinsic chromatin-based timing mechan...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Development
Autori principali: Mouilleau, Vincent, Vaslin, Célia, Robert, Rémi, Gribaudo, Simona, Nicolas, Nour, Jarrige, Margot, Terray, Angélique, Lesueur, Léa, Mathis, Mackenzie W., Croft, Gist, Daynac, Mathieu, Rouiller-Fabre, Virginie, Wichterle, Hynek, Ribes, Vanessa, Martinat, Cécile, Nedelec, Stéphane
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Company of Biologists Ltd 2021
Soggetti:
Human Development
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8034877/
https://ncbi.nlm.nih.gov/pubmed/33782043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.194514
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