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A study on the structure, mechanism, and biochemistry of kanamycin B dioxygenase (KanJ)—an enzyme with a broad range of substrates

Kanamycin A is an aminoglycoside antibiotic isolated from Streptomyces kanamyceticus and used against a wide spectrum of bacteria, including Mycobacterium tuberculosis. Biosynthesis of kanamycin involves an oxidative deamination step catalyzed by kanamycin B dioxygenase (KanJ), thereby the C2’ posit...

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Bibliografische gegevens
Gepubliceerd in:FEBS J
Hoofdauteurs: Mrugała, Beata, Miłaczewska, Anna, Porebski, Przemyslaw Jerzy, Niedzialkowska, Ewa, Guzik, Maciej, Minor, Wladek, Borowski, Tomasz
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2020
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8034593/
https://ncbi.nlm.nih.gov/pubmed/32592631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/febs.15462
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