Identification of Small-Molecule Inhibitors of Human Inositol Hexakisphosphate Kinases by High-Throughput Screening

[Image: see text] Inositol hexakisphosphate kinases (IP6Ks) catalyze pyrophosphorylation of inositol hexakisphosphate (IP6) into inositol 5-diphospho-1,2,3,4,6-pentakisphosphate (IP7), which is involved in numerous areas of cell physiology including glucose homeostasis, blood coagulation, and neurol...

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Pubblicato in:ACS Pharmacol Transl Sci
Autori principali: Liao, Gangling, Ye, Wenjuan, Heitmann, Tyler, Ernst, Glen, DePasquale, Michael, Xu, Laiyi, Wormald, Michael, Hu, Xin, Ferrer, Marc, Harmel, Robert K., Fiedler, Dorothea, Barrow, James, Wei, Huijun
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2021
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8033760/
https://ncbi.nlm.nih.gov/pubmed/33860201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsptsci.0c00218
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