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The Dose-Dependent Pleiotropic Effects of the UBB(+1) Ubiquitin Mutant
The proteolytic machinery activity diminishes with age, leading to abnormal accumulation of aberrant proteins; furthermore, a decline in protein degradation capacity is associated with multiple age-related proteinopathies. Cellular proteostasis can be maintained via the removal of ubiquitin (Ub)-tag...
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| Publicado no: | Front Mol Biosci |
|---|---|
| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Frontiers Media S.A.
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8032880/ https://ncbi.nlm.nih.gov/pubmed/33842548 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmolb.2021.650730 |
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