Disparate bone anabolic cues activate bone formation by regulating the rapid lysosomal degradation of sclerostin protein

The downregulation of sclerostin in osteocytes mediates bone formation in response to mechanical cues and parathyroid hormone (PTH). To date, the regulation of sclerostin has been attributed exclusively to the transcriptional downregulation of the Sost gene hours after stimulation. Using mouse model...

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Bibliografski detalji
Izdano u:eLife
Glavni autori: Gould, Nicole R, Williams, Katrina M, Joca, Humberto C, Torre, Olivia M, Lyons, James S, Leser, Jenna M, Srikanth, Manasa P, Hughes, Marcus, Khairallah, Ramzi J, Feldman, Ricardo A, Ward, Christopher W, Stains, Joseph P
Format: Artigo
Jezik:Inglês
Izdano: eLife Sciences Publications, Ltd 2021
Teme:
Cell Biology
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8032393/
https://ncbi.nlm.nih.gov/pubmed/33779549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.64393
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